Isotretinoin
| Description | Isotretinoin (Isotroin) is a vitamin A derivative used to treat acne. It works by reducing sebum production, fighting acne-causing bacteria, and reducing inflammation. It is effective not only for typical acne but also for severe inflammatory acne. It’s the only treatment that can lead to a long-term improvement in acne-prone skin even after the treatment period ends. Additional benefits may include smaller pores, brighter skin tone, and reduced pigmentation. |
| Risks | Dry lips, dry eyes, itching, redness, etc. |
| Price | 30 Tablets / ¥30,000 |
Recommended for People Who:
- Have severe acne.
- Want to reduce redness from acne.
- Have tried various acne treatments without success.
- Experience excessive facial oiliness.
- Want to improve oily skin.
- Are concerned about enlarged pores.
- Want to improve overall skin quality.
Before & After Photos
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
▼Treatment Name▼Price▼Description▼Risks▼Precautions During Treatment
▶
Isotretinoin (Acne Treatment)- Usually ¥1,000 per day
└Prescribed in units of 1 box
└20 mg Tablets – Pack of 30
└¥30,000 (tax incl.) - Blood Test ¥3,500 (tax incl.)
└Initial & As Needed
▶
Isotretinoin (Acne Treatment)This treatment involves the use of isotretinoin, a vitamin A derivative, for managing acne. Isotretinoin is highly effective in reducing sebum production, and also exhibits strong antibacterial and anti-inflammatory properties against Cutibacterium acnes. It is particularly beneficial for patients with severe inflammatory acne. Uniquely, this treatment may also help improve the underlying skin condition, making it less prone to acne even after the treatment course is completed. Additional benefits may include improvements in overall skin texture, such as reduction of comedones and minimization of pores, brightening of skin tone, and lightening of hyperpigmentation.
While isotretinoin is widely recognized in Western countries as a first-line, essential medication for acne treatment, it is not currently approved by the Japanese Ministry of Health, Labour and Welfare, and therefore is not covered by public health insurance in Japan. The treatment has a reported efficacy rate of over 98% in improving acne; however, the recurrence rate—defined as the return of new acne lesions to more than one-third of the pre-treatment level after completing the course—is approximately 30%.
In most cases, treatment begins with one 20mg tablet per day, taken continuously on a monthly basis. If symptoms do not improve, the dosage may be increased.
Once symptoms stabilize and improve, the dosage is gradually reduced on a monthly basis.
Costs for this treatment may vary depending on the individual.
▶
Isotretinoin (Acne Treatment)- Teratogenicity (Risk of Birth Defects): This medication is known to cause birth defects if taken during pregnancy. Therefore, it must not be used by individuals who are currently pregnant, breastfeeding, or planning to become pregnant in the near future. Strict contraception is required during the course of treatment and for at least one month after discontinuation. In addition, blood donation is prohibited during this period.
- Blood Donation: Blood donation is prohibited during the course of treatment and for at least one month after discontinuation.
- Allergic Reactions and Contraindications: This medication should not be used by individuals who have had allergic reactions to isotretinoin in the past, or by those currently taking tetracycline antibiotics (such as doxycycline [Vibramycin®] or minocycline [Minomycin®]). The concurrent use of low-dose oral contraceptives is not only safe but generally recommended.
- Mucosal Dryness: Common side effects include dry lips, dry eyes, and nosebleeds. These symptoms are typically manageable with over-the-counter moisturizers such as lip balm, artificial tears, or petroleum jelly. If symptoms are severe, please return for a follow-up consultation.
- Skin Irritation, Redness, and Fatigue: In rare cases, skin may become more sensitive to irritation, or patients may experience unusual fatigue. Please consult us if any of these symptoms become pronounced.
- Mood and Mental Health Changes: Emotional changes such as irritability or depression may occur. If you notice any psychological symptoms, please inform us immediately. This medication is not recommended for individuals currently undergoing treatment for mental health conditions, such as depression.
- Hepatitis, Pancreatitis, and Inflammatory Bowel Disease: Liver dysfunction may occur in less than 1% of patients. Therefore, blood tests (additional fee) will be required at the start of treatment, during dosage adjustments, and at maintenance stages. This medication is contraindicated in patients with high triglyceride or cholesterol levels, or those undergoing treatment for liver disease, if deemed inappropriate by the physician. In rare cases, pancreatitis or conditions such as ulcerative colitis may occur.
- Other Rare Side Effects: Headache, nausea, diarrhea, sleep disturbances, vision changes (e.g., night blindness), and hair thinning have been reported. If any of these symptoms occur, please return for a follow-up consultation.
- Patients under 15 years old: The use of this medication is not recommended for individuals under the age of 15, as it may lead to premature closure of growth plates and result in reduced height growth.
▶
Isotretinoin (Acne Treatment)- Skincare and Supplements: Please ensure proper skin moisturization and sun protection, and avoid taking vitamin A-containing supplements during treatment.
- Medication Period: If any side effects occur, the treatment may need to be discontinued. However, please do not stop the medication on your own and follow the prescribed dosage and schedule. Continuous use for at least 4 months is recommended.
- Other Concerns: If you have any questions or notice anything unusual, please do not hesitate to contact us.
What Is Isotretinoin (Acne Treatment)?
Isotretinoin (also known as Isotroin) is an acne medication primarily composed of a vitamin A derivative.
Isotretinoin is highly effective in
suppressing sebum production and has
strong antibacterial and anti-inflammatory effects against acne-causing bacteria. It is effective not only for common acne but also for
severe inflammatory acne.
Furthermore, it is
the only treatment that can improve your skin’s condition to reduce acne recurrence even after the treatment ends.
Additional benefits include
reducing clogged pores and pore size,
brightening skin tone, and
lightening dark spots, leading to overall skin quality improvement.
While isotretinoin is widely recognized as a fundamental treatment in Western countries, unfortunately, it is not yet approved by Japan’s Ministry of Health, Labour and Welfare, and therefore is not covered by insurance here.
If any side effects occur, treatment may need to be discontinued.
Please do not stop the medication on your own, as doing so may cause rebound acne or liver dysfunction. Always follow the prescribed dosage and instructions carefully.
▼For more information on isotretinoin (Link to the Ministry of Health, Labour and Welfare website)
http://www.mhlw.go.jp/topics/bukyoku/iyaku/kojinyunyu/050609-1b.html
Blood Tests for Isotretinoin (Acne Treatment)
During isotretinoin treatment, blood tests are conducted at the initial visit and as needed throughout the course of treatment.
A separate fee for each blood test will be required.
Continuing Isotretinoin (Acne Treatment)
Isotretinoin treatment typically begins with one 20mg tablet per day, taken daily.
Depending on how your acne responds, the dosage may need to be increased during the course of treatment.
Since treatment usually continues for around 6 months, it is important to consider both the financial aspect and to plan your visits carefully to avoid interruptions.
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Precautions
- Teratogenicity: This medication may cause birth defects if pregnancy occurs during the treatment period. Contraception is required during treatment and for 1 month after stopping the medication. Not suitable for those who are pregnant, planning to become pregnant soon, or breastfeeding.
- Skin Care: Maintain proper skin hydration and sun protection. Avoid taking supplements that contain vitamin A.
- Side Effects: If any side effects occur, treatment may need to be discontinued.
- Do Not Discontinue on Your Own: Stopping the medication without medical guidance can lead to rebound symptoms or liver dysfunction. Always follow the prescribed dosage and schedule.
- Blood Donation: Do not donate blood during treatment and for 1 month after finishing the medication.
Price List (Tax Included)
| Treatment Name | Details / Amount | Price | Notes |
|---|
| Isotretinoin | 20 mg Tablets – Pack of 30 | ¥30,000 | Prescribed in units of 1 box. Start with 1 tablet per day; dosage may be increased if necessary. Continued use for approximately 6 months is recommended. |
|---|
| Blood Test | ¥3,500 | Initial & As Needed Monitor Discount: 10% OFF |
Treatment May Be Declined in Certain Cases
・Pregnant or breastfeeding
・Unable to use contraception
・Taking tetracycline antibiotics (e.g., Vibramycin, Minomycin)
・Undergoing treatment for mental health conditions (e.g., depression)
・History of liver dysfunction
・History of ulcerative colitis
・Under 15 years old (due to risk of premature growth plate closure and impact on height)
FAQ
Can I get sun exposure during treatment with isotretinoin (Isotroin: a Vitamin A derivative for acne treatment)?
Isotretinoin increases photosensitivity. Therefore, you may develop sensitivity to sunlight during treatment. Please avoid sun exposure while taking isotretinoin.
ニキビ治療薬のイソトレチノイン（イソトロイン・ビタミンA誘導体）での治療中にレーザー治療は受けられますか？
クリニックによって決め事が異なります。
イソトレチノイン（イソトロイン・ビタミンA誘導体）内服中は、特に唇の乾燥や肌の過敏さが増して皮むけするなども、通常の経過としてあり得ます。そのような肌の状況でレーザー照射を行うことは、ダメージが強いと判断し、弊院では
イソトレチノイン治療中のレーザー治療はお控えいただいております。
Can isotretinoin (Isotroin: a Vitamin A derivative for acne treatment) be purchased at pharmacies?
Isotretinoin is a prescription medication and cannot be purchased over the counter at pharmacies. At our clinic, it will only be prescribed after a thorough consultation with one of our physicians, if deemed necessary.
Please also note that personal importation of isotretinoin is prohibited for the same regulatory reasons.
Can minors receive treatment with isotretinoin (Isotroin: a Vitamin A derivative for acne treatment)?
Treatment is possible for minors, but requires accompaniment by a legal guardian and a signed consent form. However, for those under 15 years old, there is a risk of premature closure of growth plates which can halt height growth. Therefore, treatment is generally not recommended for this age group.
Note: Our clinic provides only private (self-paid) medical services.
Some treatments include unapproved pharmaceuticals and medical devices.
Pharmaceuticals and medical devices used in treatments may be procured through personal importation under the discretion of our clinic’s physicians.
This website is published in accordance with medical advertising guidelines under the supervision of medical doctors.
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